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4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid

Development stage: Unknown
Modality: Small Molecules

Overview

A synthetic small molecule featuring a spirocyclic triazaspirane core with a benzylphosphonic acid moiety and naphthyl substituent. It is not an approved pharmaceutical drug but is used as a chemical probe or ligand in structural biology studies. The compound has been co-crystallized with the SH2 domain of growth factor receptor-bound protein 2 (GRB2), indicating it acts as an inhibitor or binder to this protein-protein interaction domain. GRB2 is involved in signal transduction pathways related to cell growth and differentiation; thus this compound may serve as a tool for studying SH2-mediated signaling events or for developing inhibitors targeting GRB2-related pathways[3][6]. No clinical use or therapeutic indication has been reported.

Other names: ((4-((10R,11E,14S,18S)-18-(carbamoylmethyl)-14-(naphthalen-1-ylmethyl)-8,17,20-trioxo-7,16,19-triazaspiro(5.14)icos-11-en-10-yl)phenyl)methyl)phosphonic acid({4-[(10R,11E,14S,18S)-18-(carbamoylmethyl)-14-(naphthalen-1-yImethyI)-8,I7,I0-trioxo-I6,I9-triazaspiro[5.I4]icos-II-en-I0-yI]phenyl}methyl)phosphonic acid{4-[ (10R , 11E , 14S , 18S ) - 18 - ( carbamoylmethy l ) - 1 4 - ( naphthalen - I y l methyl ) - 8 , I7 , I0 trioxo-I6,I9-triazaspiro[5.I4]icos-II-en-I0-yI ] phenyl } methyl phosphonic acid

Targets

GRB2 (Growth factor receptor-bound protein 2)

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